Ingredients

Glutamine or acetyl glutamine

Source: natural

It is non-essential and conditionally essential amino acid, meaning the body can usually synthesize sufficient amounts of it, but in some instances of stress, the body’s demand for glutamine increases, and glutamine must be obtained from the diet. In blood, glutamine is the most abundant free amino acid. Glutamine helps skin cells function optimally for smooth, radiant, healthy-looking skin. Furthermore, Glutamine is scientifically proven to play an important role in the growth of fibroblast cells. Collagen is the protein that gives skin its youthful firmness, and it makes up 75% of our skin. As we age, the amount of collagen that we naturally produce begins to decline, and therefore, the breakdown of collagen and exposure of skin to damaging ultraviolet radiation from the sun leads to the formation of wrinkles and sagging skin. Glutamine helps to reverse these effects of ageing by significantly increasing collagen production within the skin – reversing the effects of ageing, restoring skin’s natural tone, and smoothing out the texture.  Acetyl glutamine is an improved form of glutamine.

Where you can find it:  MESO LIFT, MESO REPAIR, LIFT SLEEPING MASK, EYE SORBET

L-carnitine

Source: natural

It is an amino acid derived building block (it’s produced in the body naturally) for proteins that assists with the breakdown of fats and lipids. It helps the body turn fat into energy. L-carnitine is responsible for transporting long-chain fatty acids to the mitochondria, where energy is then produced as the fat is oxidised and used for fuel. More than 95% of the body’s L-carnitine is found in skeletal muscle (which is connected to the skeleton), along with trace amounts in the liver and blood.

Where you can find it: F-CARNITINE, F-XBC

Taurine

Source: synthesis

Taurine is considered one of the most important amino acids, it is used in skin care products, particularly anti-ageing lines, where it is said to help calm the skin. The primary role of taurine in the human system is as an antioxidant – which is one reason it helps to reduce inflammation. In skin care, taurine is a powerful form of anti-fatigue. When applied topically, taurine re-energises skin to minimise the signs of fatigue. It boosts circulation and inter-cellular energy—helping with rehydration; so your skin instantly looks and feels more awake. And with continued use, taurine can give you real improved radiance with a renewed glow.

Where you can find it: F-XBC, F-XFC, F-XFC+, F-SLIM LIFT

Exfoliating enzymes

Source: bio-fermentation (produced from bacteria)

Gently eliminates the dead cells to reveal younger, healthier looking skin. An enzymatic exfoliation based on a protease obtained by fermentation. Enzymatic action that eliminates dead skin cells to smooth the skin’s surface and promote cell renewal. A gentle, enzymatic alternative to AHAs.

Where you can find it: HYALURONIC PEEL

Vectorized lipase & hyaluronidase

Source: natural & bio-fermentation (produced from bacteria)

Two enzymes, lipase and hyaluronidase, combined with maltodextrins and micro-encapsulated. Maltodextrins are linear oligosaccharides obtained from malt hydrolysis, so they can be considered biotechnological products originating from plant raw materials. Apart from the considerable moisturising properties typical of sugar molecules, maltodextrins protects the active principle, improving the stability. In particular, the enzymes complexed with maltodextrins maintain longer their activity once included in the finished product, which makes it possible to take the maximum advantage of their properties. Lipase is an enzyme acting specifically on triglyceride hydrolysis, thus reducing adipose storages. Hyaluronidase exerts its specific activity of hydrolysis on hyaluronic acid, determining a decrease of water retention typically present in cellulite. The regular application improves skin appearance, significantly reducing the signs of cellulitis. The possible association with herbal extracts can further enhance the activity of the product.

Where you can find it: F-XBC

EFG epidermal growth factor

Source: bio-fermentation (produced from bacteria)

EGF is produced by modern bioengineering method-fermentation, using glucose as raw material. It has the same molecular structure and biological activity as EGF secreted naturally by the human body. It can promote the epidermis cell growth, thus can be applied in anti-wrinkle and anti-ageing. In addition, it can also brighten the skin and remove wrinkles. EGF participates in skin regeneration through stimulation, proliferation and migration of keratinocyte, endothelial cells and fibroblasts.

Where you can find it: F-XFC+, F-LIFT+ FACE, F-MESOMATRIX, F-HA ULTRA, MESO LIFT, MESO REPAIR, EYE SORBET, LIFT SLEEPING MASK

FGF fibroblast growth factor

Source: bio-fermentation (produced from bacteria)

FGF is produced by modern bioengineering method-fermentation, using glucose as raw material. It has the same molecular structure and biological activity as FGF secreted naturally by human body. FGF (basic and acidic forms) stimulate the growth and mitogenesis of fibroblast cells. FGF participates in skin regeneration by increasing the production of collagen and elastin in fibroblast cells. Basic FGF (FGF-2) in particular activates also the synthesis of hyaluronic acid.

Where you can find it: F-XFC+, F-LIFT+ FACE, F-GLOW LIFT, F-HA ULTRA, F-MESOMATRIX, F-LIFT+ BODY, F-HAIR MEN,  MESO LIFT, MESO REPAIR, EYE SORBET, LIFT SLEEPING MASK

IGF1 insuline like growth factor

Source: bio-fermentation (produced from bacteria)

Insulin-like growth factor (IGF-I), is one of the body’s many growth factors. Insulin-like growth factors are substances that promote growth in the muscles. IGF-I regulates the anabolic effects. It goes to the muscles and ligaments where it develops lean tissue. By traveling to the fat cells, IGF-I burns fat. Subsequently, it increases lean body mass and decreases fat by helping you burn fat, and builds up
physical endurance. It increases protein synthesis, which in turn prompts tissue repair and accelerates skin recovery after aesthetic procedures. At the dermal level IGF-a helps to restore the phospholipid profile of the skin, it has a synergic effect with EGF on skin regeneration. IGF-1 increases the synthesis of hyaluronic acid and chondroitin sulfate proteoglycan by fibroblasts.

 

Where you can find it: MESO LIFT, MESO REPAIR, EYE SORBET, LIFT SLEEPING MASK

TRX thioredoxin growth factor

Source: bio-fermentation (produced from bacteria)

A multi functional protein able to protect the skin from inflammation and photo-ageing caused by ROS, MMP-9 and TNFα induced by radiation. Moreover, it can decrease the content of superficial melanin helping to even and illuminate skin tone.

Where you can find it: F-LIFT+ FACE, F-RADIANCE

VEGF vascular endothelial growth factor

Source: bio-fermentation (produced from bacteria)

Vascular Endothelial Growth Factor stimulates new blood vessel formation. VEGF, which stimulates vasculogenesis and angiogenesis, is one of the most important proangiogenic factors in the skin. VEGF is present at high levels in cutaneous wounds, and multiple cells types, including keratinocytes, macrophages, and fibroblasts that produce VEGF in response to injury. The importance of VEGF in the repair process is well documented, especially as a proangiogenic factor. In hair growth stimulation VEGF creates new blood vessels to improve blood supply to hair follicles that increase nutrient feeding.

Where you can find it: F-COUPERIX, F-HAIR MEN, F-PERFECT LIPS, MESO LIFT, MESO REPAIR, EYE SORBET, LIFT SLEEPING MASK

Calcium

Deficiency of key nutrients, especially calcium will cause imbalance in our body which in turns affect hair health. Although it is essential to note the advantages of calcium for hair, yet knowing the consequences of a lack in calcium is equally important. Calcium also helps with the contraction and relaxation of muscles, nerve signalling, blood clotting, and with the secretion of hormones and enzymes. Hormones such as androgens, stimulate hair growth; enzymes such as biotin promote cell growth and strengthens healthy growing hair & skin.

Where you can find it: F-XFC, F-XFC+, F-SLIM LIFT, F-HAIR

Copper

Copper is commonly used in food, cosmetics and other fields. It can be used to treat medical conditions like copper deficiency that often leads to anemia. It also has anti-oxidant and anti-inflammatory effects, helping cellular regeneration, restoring skin vitality and immunomodulatory function, delaying senescence.

Where you can find it: F-XFC, F-XFC+, F-SLIM LIFT, F-HAIR

Iron

Iron helps boost circulation and carries oxygen to your hair’s roots, which helps the hair grow faster and longer. An iron deficiency can lead to hair loss. Some good sources of iron include clams, beans, lentils, pumpkin seeds, sesame seeds, oysters, grass-fed beef and bison. Iron contributes to the production of hemoglobin in your body. Hemoglobin delivers nutrients and oxygen to your hair’s cells, which is vital for their growth. This process is interfered due to a lack of iron, which also means low hemoglobin levels, leading to loss of hair.

Where you can find it: F-XFC, F-XFC+, F-SLIM LIFT, F-HAIR

Magnesium

Magnesium plays a number of roles in the body, being required for more than 325 enzymatic reactions, including those involved in the synthesis of fat, protein and nucleic acids, neurological activity, muscular contraction and relaxation, cardiac activity and bone metabolism. It also helps prevent calcium build up on your scalp. When calcium clogs hair follicles, your scalp will be dry, flaky, and you could even see some hair loss. These calcium deposits on and around the hair follicles can increase over time due to scalp inflammation. Also magnesium helps with protein synthesis. Since hair follicles are made almost entirely of protein, this is key. Better protein synthesis means healthier hair and a predictable hair cycle with normal growing and resting stages. Protein synthesis also helps create melanin, which helps prevent your hair from going grey.

Where you can find it: F-XFC, F-XFC+, F-SLIM LIFT, F-HAIR

Zinc

Zinc is crucial for helping to heal wounds and boost immunity, and it also supports a healthy blood supply. In other words, it’s a mineral bodybuilders should emphasize through diet and supplementation. Zinc also supports sleep quality and recovery after hard workouts, and it improves your body’s ability to use calories you’ve consumed for fuel rather than shuttling them to storage as fat. Zinc plays three main roles in your body, all of which are crucial to muscle growth and development. Zinc accelerates muscle building chemical reactions, stabilizes protein structures and regulates your hormone levels. Functions like these help the muscle protein synthesis process that kicks in after a resistance
training workout.

Zinc is involved in hair growth and keeps the oil glands around the hair shaft working properly. Zinc plays an important role in hair tissue growth and repair. It also helps keep the oil glands around the follicles working properly. Zinc is also believed to play a crucial role in DNA and RNA production. This is required for the normal division of hair follicle cells, leading to healthier hair growth. Zinc also may help keep hormone levels balanced, which could be one of the reasons why it is so effective in preventing hair loss. There are even a few outlying studies in which people’s greyed, aged hair returned to its original colour when nourished with zinc-rich diets or hair growth supplements. As a bonus, zinc for hair growth may help eliminate dandruff on the scalp as well.

Where you can find it: F-XFC, F-XFC+, F-SLIM LIFT, F-HAIR, F-ACN

Arbutin

Arbutin is a widely used skin lightening agent derived from hydroquinone. It is all-natural and can be extracted from bearberry, cranberry, blueberry, and pears. Arbutin’s power in reducing hyperpigmentation has been proven and confirmed by various studies over the years. A 2018 study published in Cosmetic Facial Surgery found that arbutin effectively reduced melanin content to approximately 39%. Aside from skin lightening, arbutin also has antioxidant properties that improve skin texture. It’s also used in anti-ageing products because of these characteristics.

Where you can find it: F-MELACLEAR

Artichoke extract

Artichokes are super rich in antioxidants, which improve skin health and appearance and slow down skin ageing. They are also rich in vitamin C, which is one of the biggest contributors to healthy collagen development and artichokes aid detoxification. The antioxidants in artichokes also prevent oxidative stress, which affects skin health. The leaf extract also contains another important chemical called cynaropicrin, which reduces the damage caused by UV rays and protects the skin. For the treatment of fat, artichoke is a naturally diuretic plant. Indeed, it promotes the renal elimination of water and the drainage of water retained in the tissues. Thus, artichoke is excellent to fight against cellulite.

Where you can find it: F-MAGISTRAL, F-XBC, F-ARTICHOKE

Centella asiatica extract (Cica)

Source: natural, extracted of centella asiatica leaves.

Centella asiatica was first valued in pharmaceutical applications for its reparation properties. Cica extract is highly purified in triterpene molecules, for its restorative properties on cosmetic and dermo-cosmetic applications. Cica accelerates the skin repair process in damaged skin and acts on the restoration of its integrity. Our cica extract is produced from centella asiatica leaves harvested in Madagarscar. The extract is highly purified to reach the highest concentrations in Asiaticoside, Madecassic Acid and Asiatic Acid. Centella asiatica is also referred as “tiger grass” or “tiger herb”.

Cica works to repair damaged skin and restoring skin integrity: by boosting the vital proteins within the dermis, by soothing effect. The interest of Cica in  skincare and for post medical procedures is of high interest. Faster repair of damaged skins, skin remodeling, redensifying, anti-stretchmarks. Products can be used to repair the skin faster after laser, peelings, meso-needling and many other treatments where the skin integrity is damaged.

Clinical study on skin repair after laser treatment:
– 34% improvement in dermis density with cica versus placebo 24 hours after the first application vs placebo.
– 60% improvement in dermis density with cica versus placebo 4 days after treatment vs placebo.
– No more inflammation with cica after 4 days, 10 days earlier than placebo.
– At 14 days the skin has recover its density while placebo still shows a significant decrease of density.

Where you can find it: F-MESOMATRIX, F-XBC, F-HAIR, CICA POST-CARE

Coumarin

Coumarins are a large group of substances, primarily of plant origin. Like their more intensively examined congeners flavonoids, many of them are antioxidants. Coumarins exhibit direct effects on the cardiovascular system which are not based on antioxidant activity. Moreover, coumarins have been shown to possess antiplatelet and vasodilatory potential. Interestingly, the former effect may be mediated by the inhibition of various pathways leading to platelet aggregation, their differing effects on those pathways being due to structural differences between the various coumarins.

Where you can find it: F-MAGISTRAL

Gingko extract

In the Far East,  ginkgo is known for its remarkable longevity, it seems that it can live up to 4,000 years. It is the only tree that survived Hiroshima in 1945. It’s active constituents are flavonglycosides (Ginkgolide hetersides) quercitin, proanthrocyanidins, lactones and terpenes. Gingko offers anti-ageing, photoprotection, hair colour protection, re-epithelizing,  anti-irritation, blood circulation stimulation. It also acts as a decongestant and has anti-cellulite benefits. Ginkgo leaf extract contains quercetin and kaempferol, natural plant flavonoids that act as antioxidants, and help fight free radicals. These components may result in anti-inflammatory and anti-ageing effects. Ginkgo contains a powerful inhibitor of tyrosinase, which is an enzyme responsible for the development of pigment in the skin. Hence ginkgo extracts, when applied to the skin may result in a skin lightening effect. This is particularly desirable for consumers who wish to combat pigmentation and age spots, and maintain a lighter skin tone. Microcirculatory effects (the ability to dilate and increase blood flow in small blood vessels). Studies have shown the ability of ginkgo to enhance blood flow in the skin. Increased blood flow may help speed up skin healing. This may also result in a local synergistic effect, whereby the availability and impact of other ingredients in the area where it is applied is enhanced.

Where you can find it: F-COUPERIX, F-XBC, F-GINKGO, F-HAIR

Melilotus extract

Used to increase the loss of water from the body through the urine (as a diuretic). It is also used for varicose veins and to relieve symptoms of poor blood circulation (chronic venous insufficiency) including leg pain and heaviness, night cramps, itchiness, and fluid retention (oedema). Melilotus is sometimes used along with regular medicines for treatment of blood clots in the veins. Other uses include treatment of blockage of the lymphatic system. The lymphatic system drains fluid from tissues. Some people apply it directly to the skin for bruises.

Where you can find it: F-XBC, F-HAIR MEN, F-MELIRUTIN

Rutin

Rutin has the capacity to regenerate vitamin C after it neutralizes a free radical, thus helping to restore its antioxidant potential. Because vitamin C plays a critical role in the manufacture of collagen, an important component of capillary walls as well as the sustaining framework of the epidermis, this could have a dramatic impact on the health of your skin. Rutin has the ability to protect skin from damage caused by advanced glycation end products (AGEs). AGEs accelerate the ageing of skin cells, which cause the skin to lose elasticity and collagen. One clinical study found that rutin can effectively modulate the breakdown of collagen caused by AGEs. Rutin’s ability to provide microvascular protection, improve circulation, and defend against free radical damage makes it an excellent ingredient in any natural skin care formulation for ageing skin.
Also, because rutin can penetrate the skin, it makes it extremely valuable.

Where you can find it: F-MAGISTRAL

Troxerutin

Is anti-inflammatory ingredient that keeps skin balanced and even toned. It appeases the irritated tissue and helps to regenerate healthy skin. It decreases the formation of inflammation mediators to a great extent.

Where you can find it: F-MAGISTRAL

Vegan ceramides

Source: natural, extracted from rice.

Vegan ceramides is a rice extract made with a process to optimize the sphingolipids and phospholipids fraction. Ceramides play an important role in the structure and quality of the stratum corneum. Ceramides represent the main components of the intercellular lipid cement (40%).

They control several essential biological functions:
– regulation of the trans-epidermal water flow.
– cohesion of the stratum corneum layers and protection of the skin.
– restoration of the skin barrier.

Where you can find it: CERAMID MOISTURIZER

Acetyl glycyl beta-alanine peptide

Source: bio-fermentation (produced from bacteria)

At low concentration this whitening peptide brings outstanding performances in melanin reduction and inhibition of melanosome transport and melanin-generating enzymes tyrosinase, TR-1 and TR-2. This peptide also functions genetically to diminish the melanin-promoting transcription factor MITF. Ex-vivo and in-vivo testing both indicate its significant effectiveness in spot whitening within only 9 and 14 days, respectively. Proven by a series of extensive studies, this peptide is an extremely powerful, fast acting spot correcting agent that is safe and stable.

Where you can find it: F-RADIANCE

Acetyl hexapeptide-37

Source: Synthesis

Hexapeptide that enhances aquaporin 3 (AQP3) expression, improving the water flux from the basal layer of the epidermis to the stratum corneum. Skin hydration is not only preserved but raised with this hexapeptide. Furthermore, it improves the barrier function and increases collagen I synthesis and keratinocyte proliferation, providing a complete treatment against skin ageing.

Skin not only protects us against the environment but regulates water exchange. Water is essential for the normal functioning of the skin, especially for the stratum corneum (SC) and skin barrier properties. Mechanisms that control water transport are not fully understood, but there is a continuous exchange of water between the SC, the living cells in the underlying epidermis and the atmosphere. Aquaporins are integral membrane proteins involved in water transport through the different tissue layers, acting as water selective pores. AQP3 is the most abundant aquaglyceroporin in the human epidermis, facilitating the transport of water, glycerol and other small solutes. Therefore, AQP3 improves transepidermal permeability, increasing water content in the skin surface and helping the barrier function.

This peptide enhances AQP3 expression levels in keratinocytes, which are inherently reduced due to chronologic aging and photoaging. In addition, this peptide presents further properties that contribute to maintaining skin barrier integrity and a youthful appearance.

Where you can find it: F-HYDRALIX

Acetyl hexapeptide-38

Source: Synthesis

Hexapeptide that increases fatty tissue volume in specific areas improving facial appearance and providing attractive body curves. This peptide stimulates peroxisome proliferator- activated receptor gamma coactivator 1α (PGC-1α) expression, enhancing adipogenesis rate. This leads to a higher lipid accumulation and volume growth in the desired areas like lips.
When ageing, skin gets thinner, loses firmness and gravity pulls it downwards leading to undesired and visible changes in the face and body. Furthermore, adipose tissue, which is mostly found beneath the skin and acting as a supporting tissue, gets redistributed and decreases in areas like cheeks, facial oval, breasts or lips. Nowadays, the relevance of perfect lips make people look for efficient and non-aggressive ways of increasing tissue volume. PGC-1α is a transcriptional coactivator that, interacting with the peroxisome proliferator- activated receptor PPARγ, modulates adipogenesis rate. This peptide increases local volume improving facial appearance, by promoting PGC-1α expression and lipid accumulation in the adipose tissue.

Where you can find it: F-PERFECT LIPS

Acetyl tetrapeptide-3 & red clover extract

Source: Synthesis & natural

The importance of hair in our lives cannot be overstated. Whether men or women lose their hair, they lose much more than their natural, youthful appearance. People also lose their self-esteem and self-confidence associated with healthy looking hair. Hair loss also, called alopecia, is a common problem affecting both men and women. Acetyl tetrapeptide-3 is an innovative and unique active complex designed to prevent, and stop the hair loss process and stimulate hair growth. It is a biomimetic peptide (acetyl tetrapeptide-3) combined with a red clover extract rich in Biochanin A. The efficacy is based on the combined and synergistic action of its two ingredients. Normal hair follicle is surrounded by healthy connective tissue and dermal papilla, and has minimal or absence of inflammation nor oxidative stress. Hair loss sufferers will most of the time have the hair growth cycle disrupted by an increase of dihydrotestosterone (DHT) hormone, loss of connective tissue integrity surrounding the hair follicle, and an increase of the inflammatory process and oxidative stress in the scalp. With
age, the decrease number and size of hair follicles in the scalp will also lead to thinner hair and an increase in hair loss.

Acetyl tetrapeptide-3 has a direct action on 5- -reductase which modulates dihydrotestosterone (DHT) to prevent hair miniaturization. It improves ECM proteins integrity in dermal papilla for a better hair anchoring. Acetyl tetrapeptide-3 also reduces damages caused by inflammation, providing maximal efficacy to reduce the hair loss process and stimulate hair growth.

• Decreases pro-inflammatory cytokines with a synergistic action compared to red clover extract alone.
• Biochanin A inhibits 5-α-reductase activity, thus confirming its effect on DHT production to reduce androgenic alopecia.
• Acetyl tetrapeptide-3 stimulates collagen production for better ECM integrity leading to a better hair follicle anchoring.
• Acetyl tetrapeptide-3 stimulates dermal papilla extracellular matrix proteins, and thus has a direct effect on hair follicle size and anchoring.
• Acetyl tetrapeptide-3 stimulates hair growth with higher activity than the reference hair growth agent, Minoxidil®.

Clinical efficacy:
• Induces a 15% increase in the anagen hair density in comparison with placebo, demonstrating its stimulating hair growth efficacy.
• Induces a strong reduction -52% in the telogen hair density in comparison with the placebo, which clearly indicates a reduction in the hair loss process.

Where you can find it: F-HAIR MEN

Acetyl tetrapeptide-5

Source: bio-fermentation (produced from bacteria)

As skin loses its elasticity and muscles weaken through age, loose skin can accumulate around the eyes, forming eyebags. Water accumulation is another reason for puffy eyes, also known as eyelid oedema. This accumulation is due to several vascular diseases, such as a poor lymphatic circulation or an increased capillary permeability. This peptide fights against oedema-forming mechanisms and shows a decongesting effect, enhancing elasticity and skin smoothness.

This peptide promotes the inhibition of glycation, which causes tissue damage, and reduces vascular permeability that can help minimize liquid-related eye puffiness. The ingredient is also efficient in decreasing lipid accumulation, suggesting a potential effect in minimizing eye bags caused by excess fat. Anti-dark circle effect is also achieved from the peptide due to its ability to degrade the coloured bilirubin compound.

• Prevents collagen cross-linking: Inhibition of collagen glycation avoids losing elasticity and subsequent eye bags formation.
• Draining and anti-oedema effect prevents liquid accumulation in eye bags.
• Decrease of dark circles under the eyes ITA and L* values significantly increased showing a slight lightening effect.

Where you can find it: F-EYE CONTOUR

Carcinine

Source: Synthesis

Carcinine is a nature-identical compound obtained from the decarboxylation of carnosine. Carcinine has demonstrated its ability to protect the skin integrity from oxidative stress (by detoxification, scavenging and damage repairing). Besides intrinsic ageing, the skin is under the constant aggression of oxidative entities (solar radiations, pollution, physical stress, etc.). The resulting oxidative stress can affect the structure of the cutaneous tissue and the metabolic activity of its composing cells such as fibroblasts and keratinocytes. Since these factors are essential for the quality of the skin, It is a peptidic compound which is able to protect the skin components such as the collagen from these aggressions and to
maintain the metabolic activities of the exposed cells.
Treatment will both prevent and repair the daily aggressions-induced damage, allowing the skin to remain healthy, firm and beautiful. It acts in three different, non-exclusive, ways for a maximal efficiency:

1. Anti-oxidation / anti-stress
2. Anti-glycation
3. Metabolism stimulation

For anti-glycation: protects the collagen and other proteins from the glycation processes at two different levels:
• Prevention: by glucose scavenging.
• Reparation: by substituting itself to the collagen in a transglycation process.

Hence, it prevents the protein from cross-linking, while other anti-oxidants such as vitamin E fail at it. Even more potent than aminoguanidine, a reference in anti-glycation. Furthermore, the final products of the reaction are neither toxic nor mutagenic. The skin preserves its structure and elasticity.

A unique anti-oxidant: UV radiation can induce damage that can be monitored by measuring the cells redox status. The skin can slowly recover by itself from UV irradiation. However, even after 24h, the self healing process still was not complete. Treatment with carcinine led to a full recovery in just about 8h. It provides a fast and reliable protection against oxidative stress-induced damage as demonstrated. reduces the noxious LOOH (lipid peroxide) into harmless alcohol LOH, preventing the protein degradation into toxic free radicals as assessed by HPLC. This anti-oxidative effect is unique and is not shared by other anti-oxidants such as Vitamin E. Alistin’s anti-oxidative properties are also due to its
scavenging power as shown by its ability to reduce MDA (a toxic by-product of oxidative stress) production.

Reduces skin inflammation: Aggressions can lead to skin inflammation. When applied on human reconstituted epidermis, it reduces the secretion of pro-inflammatory cytokines such as TNF-alpha, IL-1 alpha and IL-8. Hence, it has anti-inflammatory and soothing properties comparable to corticoids without the severe side effects.

Energises the skin: Sirtuins are proteins involved in aging, stress resistance and cell metabolism through their ability to maintain ATP levels. It stimulates the production of sirtuins in a dose dependant manner, hence enhancing skin cells metabolic abilities.

Stimulates collagen production: With age, the collagen production is reduced, the firmness of the skin is reduced, wrinkles appear. It stimulates fibroblastic collagen production in a dose dependant manner. The skin is denser and younger.

Improves hair density: By increasing the amount of hair in the anagen phase, a 6 month treatment, when coupled with organic silica, improves the hair density for 80% of tested alopecic men. The hair is denser, healthier.

Where you can find it: F-LIFT+ FACE, F-HAIR MEN

Copper peptide

Source: bio-fermentation (produced from bacteria)

Copper Peptide is a naturally occurring human tripeptide. In plasma, the level of Copper peptide is about 200 ng/ml at age 20. By the age of 60, the level drops to 80 ng/ml. Scientific studies conducted have established that human tripeptide Copper peptide possesses a plethora of biological actions such as activation of wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen etc. Is widely used as a reparative and anti-ageing ingredient but it also helps enlarge hair follicles and stimulate hair growth.

Where you can find it: F-HAIR MEN

IDP2 peptide

Source: bio-fermentation (produced from bacteria)

Decapeptide-4. CG-IDP2 acts as an anti-wrinkle, skin lifting and hair growth promotion active. It is a double layered encapsulated bio-mimetic peptide which strengthens skin elasticity by inducing the synthesis of collagen and elastin. It is involved in normal skin growth, healing and wound repairing. It reduces and prevents lines and wrinkles by actively generating new skin cells. Increases the cell density and longevity.

Where you can find it: F-HAIR MEN

EDP3 biomimetic peptide

Source: bio-fermentation (produced from bacteria)

Oligopeptide-24. CG-EDP3 acts as an anti-wrinkle, skin lifting and firming agent. It is a double layered encapsulated biomimetic peptide which reduces and prevents lines and wrinkles by actively generating new skin cells. It enhances skin tone, vitality and energy, and minimises scars in the skin by forming new skin cells.  It exhibits up-regulation of cell growth and migration, cell survival, extracellular matrix expression.

Where you can find it: F-LIFT+ FACE

Glutathine

Source: natural

Glutathione plays an important role in cell protection during ageing, acting both as anti-oxidant and detoxifying agent. It has very good ability to inhibit melanin synthesis and makes it an essential component of melasma and anti pigmentation treatments. It is binding itself to toxins such as heavy metals, chemical pollutants and carcinogens and transforming them into a form which can be easily flushed out of the body. It is a powerful antioxidant found within every cell protecting our cells from free radicals.

Where you can find it: F-XFC, F-XFC+, F-SLIM LIFT, F-GLOW LIFT, F-MELACLEAR, F-ANTI-OX

Hexapeptide-10

Source: Synthesis

The study of the mechanisms of skin ageing has traditionally overlooked an important area: the dermo epidermal junction (DEJ). This is the layer responsible for supporting the epidermis and for the communication between epidermal and dermal cells. The DEJ is physically a basement membrane that separates the skin cells in the epidermis from the extracellular matrix (ECM) which lies below, in the dermis. This membrane is composed by two layers, the basal lamina, in contact with the cells, and the underlying reticular lamina, in
contact with the ECM. The basal lamina is rich in collagen type IV, proteoglycans and the glycoproteins entactin and laminin. These molecules provide a structural network and bio-adhesive properties for cell attachment.

Laminin is a glycoprotein of about 850 kDa and it is, after collagen, the most abundant protein in the ECM. However, while Collagen performs exclusively a structural role in the skin, Laminin is involved in functionalisation and activation of cells, in processes such as cell proliferation, migration and adhesion. These mechanisms are necessary to keep the normal balance of the skin and are essential for processes as important as wound healing, for instance.

Laminin only exists in basement membranes. It is composed of three very long polypeptide chains (alpha, beta and gamma) arranged in the shape of an asymmetric cross and held together by disulfide bonds. The three chains exist as different subtypes which results in twelve different isoforms for laminin, of which the best well- studied is Laminin-1.

Keratinocytes recognise the binding domains on Laminin, particularly Laminin-5, by using their own integrin receptors, transmembrane proteins located on specific junction points called hemidesmosomes.

Lipotec has identified and synthesized a sequence from the alpha chain of Laminin: hexapeptide-10 . This peptide retains many of the characteristics of the native protein, and promotes cell adhesion and proliferation. Certain features of the DEJ are altered by the aging process, such as the anchoring ability of keratinocytes, probably due to deficiencies in the expression of integrins as we age. Laminin-5 synthesis has also been proved to decrease in aged skin. This causes a loss of contact between dermis and epidermis, and results in the skin losing elasticity and becoming saggy. The cohesion between dermis and epidermis is essential to maintain skin balance because it enables the transport of oxygen, nutrients and waste, contributing to the health of the epidermis.

This work will show that a synthetic hexapeptide from Laminin-1 is able to restore the skin’s normal function by promoting synthesis of Laminin-5,
stimulating keratinocyte and fibroblast proliferation, inducing a redensifying effect on the dermis, and an improvement in skin elasticity, compactness, tonicity and smoothness.

Where you can find it: F-LIFT+ FACE, F-EYE CONTOUR

Octapeptide

Source: Synthesis

Muscles beneath the skin precisely control movement of forehead, eyes, nose, lips and mouth in such a way that human face is capable of more than 10,000 different expressions. Facial expressions are vital as they are a means of communication and convey emotional states. Apart from having a role in social interaction, they influence perception of attractiveness. An expressive face is beautiful, as it transmits personality and emotions. But there is a downside, as facial expressions are linked with the formation of expression wrinkles (or mimic wrinkles). The most effective strategy to diminish the formation of expression wrinkles and their progression over time is to reduce excessive stimulation
of muscle cells.

Molecules that can modulate neuronal exocytosis can contribute to relaxing muscular tension, and therefore they can be used to reduce the appearance of wrinkles. Botulinum neurotoxins (BoNTs) are naturally-occurring proteins that act through such mechanism of action. This kind of toxins cleaves the proteins that make up the SNARE complex, blocking neuronal exocytosis at the MNJ in an irreversible manner and paralyzing muscle contraction as a result.

The injection of BoNTs to the skin avoids the formation of expression wrinkles, but this procedure is not exempt from adverse side effects including allergic reactions. In addition, due to muscle paralysis, side effects such as drooping eyelid or facial asymmetry and a loss of facial expressivity can occur. Besides, the anti-wrinkle effect lasts for a limited period of time, typically 3-4 months, requiring regular re-applications. Biomimetic competitive inhibitory peptides are developed to imitate proteins found in the skin and compete with them to modulate their functions.

The application of biomimetic peptides that compete with the skin components involved in neurotransmitter exocytosis can lessen the process of muscle contraction in a reversible and controlled manner, and thus it enables to reduce expression wrinkle formation. In addition, these small compounds can be topically applied and are not associated with adverse effects. Therefore, biomimetic inhibitory peptides are a safe alternative to BoNTs and they allow maintaining natural expressions of the face, so important to feel comfortable.

Length of these competitive peptides is critical for their inhibitory activity. Longer peptides usually have a higher similarity with the native protein, which enhances their affinity and inhibitory capacity. Peptides showing high activity can be applied topically to delay the progression of expression lines into permanent wrinkles that are deeper and more visible, especially in middle-aged women.

This octapeptide is an elongation of the revolutionary ARGIRELINE® peptide. Because these peptides are patterned after the N-terminal domain of SNAP-25, they can bind to the SNARE complex causing its destabilization. As a result, vesicles cannot release neurotransmitters as efficiently in the NMJ, therefore muscle contraction can be attenuated.

The topical application of octapeptide peptide could help to prevent the formation of lines and wrinkles caused by the repetitive contraction of muscles of facial expression with an alternate mechanism to botulinum toxin. This would apply to wrinkles that have already appeared by 30s or even before, but also to delay their progression through the 40-50s, helping to maintain a smoother skin in those areas prone to show deeper and more visible wrinkles.

The in vitro efficacy tests of octapeptide peptide have proven that it inhibits the formation of the SNARE complex and that it can also modulate the release of neurotransmitter by neuron cells. Clinical test showed a visible decrease in wrinkle depth and skin roughness after the treatments application in areas with expression wrinkles.

Where you can find it: F-BTX

Pentapeptide

Source: Synthesis

Expression wrinkles are a particular type linked to repeated muscular contraction and they usually appear as soon as the age of 30. Muscles are contracted when they receive acetylcholine released from a vesicle in the neuronal exocytosis. In order to fuse a vesicle with the cellular membrane, two events are required: the SNARE complex formation and the entry of calcium ions into the neuron. Pentapetide is a modified enkephalin that couples to the enkephalin receptor, outside of nerve cells. This association releases G protein subunits (α,ß,Y), which close calcium channels avoiding vesicle fusion and consequently inhibiting acetylcholine release across the synapse. This process maintains the neuron in its resting state, attenuating muscle contraction and preventing the formation of lines and wrinkles.

Where you can find it: F-BTX

TGP2 biomimetic peptide

Source: bio-fermentation (produced from bacteria)

Oligopeptide-34. CG-TGP2 acts as a skin lightening & brightening, sun protection, anti-ageing active. It is a double layered encapsulated biomimetic peptide which provides even skin tone, prevents photo-aging and aged spots. It significantly inhibits melanin synthesis on melanocyte cell line. CG-TGP2 has an innovative whitening efficacy of aged spots, brown spots, and improvement on photo-ageing and skin tone evenness.

CG-TGP2 mimicking peptide induces degradation of MITF, inactivates major factor for melanin generating enzymes, tyrosinase, TRP-1, TRP-2, which restraints the activation by alpha-MSH.
• Inhibits melanin synthesis and tyrosinase activity up to 58%.
• Blocks melanosome transfer from melanocyte to keratinocyte up to 30%.

Where you can find it: F-LIFT+ FACE, F-RADIANCE

Tetrapeptide

Source: Synthesis

Rosacea is said to affect 45 million people worldwide. The inflammation of capillaries and pilosebaceous units, erythema, telangiectasia (dilated capillaries), flushing skin, pustules, itching and Post-inflammatory Hyperpigmentation (PIH) are frequently associated with skin redness disarrangements. These effects are mainly located in the central third of the face.

Chronic skin redness disorder with visible capillaries can also turn the skin dull.
• It typically affects individuals with pale skin and especially women over 30s.
• Its etiology is uncertain but several factors can induce it (strong emotions, spicy food, sport practise, alcohol,…).
In the natural response of the immune system to potential harmful agents and conditions, kallikreins and antimicrobial compounds like cathelicidins have an important role. They induce the release of interleukines (IL), which are among the increased molecules in facial skin redness and vascular alterations. In skin disorders with erythema and dilated blood vessels, like rosacea, LL-37 expression is found to be abnormally high, it is locally activated and a cascade of inflammatory reactions leads to an increase of pro-inflammatory metabolites, IL-6 and IL-8 among others. The dermal connective tissue may be damaged as the proteolytic degradation of the extracellular matrix (ECM), mainly of collagen, is
increased due to Matrix Metalloproteinases (MMPs) activation. Therefore, red areas become more visible as capillaries are fragile and permeable, and blood vessels can easily dilate due to inflammation. Tetrapeptide peptide helps to decrease facial redness and other skin disorders caused by LL-37 activation and subsequent release of ILs. It also provides a photoprotective effect lowering cell damage and skin inflammation negative effects.• Lowers LL-37-mediated IL-6 and IL-8 release: IL-6 levels decreased by 24.2% and IL-8, by 22.8% with Tetrapeptides at 0.5mg/ml.
• Connective tissue degradation is reduced by Tetrapeptides that demonstrated a statistically significant inhibitory effect on collagenase activity.
• Erythema, redness and extent intensity are reduced by Tetrapeptides.
• Skin roughness diminished as well, by 7.5% at the end of the treatment.

Where you can find it: F-COUPERIX

Vitamin A (Retinol)

Source: synthesis

Regulates the processes of differentiation , proliferation and intercellular communication. When it gets into a cell, it can make a bond with nuclear
sensors. Thus, sections of the cell genome are activated or decelerated. Retinol provides minimal skin damage, a brief recovery period and a low probability of complications. Retinol can effectively cleanse the skin, has anti-inflammatory effects, makes skin glow, improves skin texture and structure, and provides a lifting effect.

Where you can find it: RETINOL 1.0, F-VITAMIN ACE

Vitamin B3 (Niacinamide)

Source: natural

Niacinamide (nicotinamide) comprises one of the two forms of Vitamin B3; niacin (or nicotinic acid) being the other, both of which provide equivalent vitamin activity. As an essential component of living cells, Vitamin B3 is essential for protein, carbohydrate and fat metabolism. Niacinamide is a precursor in the synthesis of the pyridine coenzymes NAD and NADP involved in cell metabolism, and as such play a key role in the production of energy.

 

Key attributes:
• Upregulates Aquaporin-3 (AQP3) (in vitro)
• Enhances skin tone (in vitro)
• Helps improve the overall appearance of skin
• Improving skin texture
• Evening skin complexion
• May help to reduce the appearance of acne
• May help to revitalize hair to minimize hair fall and improve its overall appearance

 

Where you can find it: F-GLOW LIFT, F-MELACLEAR, F-ACN, NIACINAMIDE 5.0

Vitamin B5 (Panthenol)

Source: natural

DL-Panthenol is the provitamin of DL-Pantothenic acid (Vitamin B5), which plays a key role in the human intermediary metabolism. Deficiency of Vitamin B5 can result in many dermatological disorders. DL-Panthenol is applied in almost all types of cosmetic preparations. It cares hair, skin and nails. It acts as a skin conditioning agent to provide deep penetrating moisture to the skin, stimulating epithelisation to provide wound healing and anti-inflammatory effects. It also functions as a hair conditioning agent to provide long lasting moisture to hair, preventing damage, thicken hair and improve luster and sheen. This product can also be used in nail care products to improve hydration and impart flexibility.

Where you can find it: F-ACN, F-HAIR, F-HAIR MEN

Vitamin B9 (Folic acid)

Source: natural

Because folic acid helps to facilitate the development of healthy skin cells, it can help fight out premature aging, specifically wrinkles and fine lines. It has also been found to increase the production of collagen to give you firmer and more toned skin. Folic acid, also known as vitamin B9, works like an antioxidant to promote cell turnover and fight free radical damage. Studies have also shown that when applied topically along with creatine, it fights signs of sun damage and ageing, leading to firmer looking skin.

 

Where you can find it: MESO LIFT, MESO REPAIR, EYE SORBET

Vitamin C (Ascorbic acid)

Source: natural

Vitamin C is a very effective anti-oxidant that neutralises free radicals – the unstable molecules that age the skin as a result of pollution, smoking and exposure to the sun. It inhibits melanin, stimulates growth of the hydro-lipid film and enhances collagen synthesis, an important skin protein that strengthens the structural support and elasticity of the skin.

Where you can find it: F-VITAMIN C, F-VITAMIN ACE, F-GLOW LIFT, F-RADIANCE,  F-EYE CONTOUR, F-ANTI-OX

ET-Vitamin C

Source: synthesis

Et-Vitamin C is a multi-functional vitamin C derivative with excellent whitening, anti-oxidation, free radical- scavenging and collagen boosting effect. Its stability is superior to other ascorbic acid derivatives. It exhibits strong inhibition effect on melanogenesis, reduces dark spots and age spots, fights photoaging by interfering with inflammatory cytokines and reverse ROS production to achieve free radical scavenging purpose.

Where you can find it: VITAMIN C 5.0

Vitamin E (Tocopherol)

Source: natural

Tocopherol is a form of Vitamin E typically derived from vegetable oils. Tocopherol is known as an antioxidant superhero that provides protection for skin. (This shouldn’t be terribly surprising, since tocopherols make up 96% of skin’s natural antioxidant defence system!). Studies show tocopherol: Absorbs UV rays and helps prevent UV-induced free radical damage to skin. Acts as an anti-inflammatory agent in the skin, helps moisturise, helps reduce pollution-related free radical damage. There’s also preliminary evidence that it can help prevent scarring and reduce the signs of aging, too.

Where you can find it: F-VITAMIN ACE

Vitamin H (Biotin)

Source: natural

Biotin, also known as vitamin B7, is a water-soluble, B-complex vitamin that contributes to healthy metabolic, nerve, digestive and cardiovascular functions. It is essential for metabolising fats and carbohydrates and works synergistically with pantothenic acid (vitamin B5) to strengthen hair, increase nail thickness and prevent split ends and thinning hair. It assists in the production of new cells and helps oil glands function properly, resulting in the healthy condition of skin.

Where you can find it: F-HAIR

Bio-revitalising complex (4 minerals, 23 amino acids, 18 vitamins, 6 co-enzymes, 5 nucleic acids, 2 reducing agents)

Source: natural

Bio-revitalisation is a non-surgical procedure used to fight skin aging and various skin problems in aesthetic medicine. This ionic balancing formula has 60 ingredients to repair the skin layers. Revitalisation actively repairs the skin to replace minerals that are deficient such as Magnesium, Sodium, Potassium and Calcium. There are 12 vitamins, Vitamins A, B, C and E are just a few that contribute to skin cell stimulation. Alongside this, there are also 23 different amino acids that help produce elastin and collagen, two significant proteins
making up the skin layers. To combat free radicals, there are also 2 anti-oxidants to ensure your skin remains healthy and glowing. Revitalisation stimulates production of skin cells so that the added nutrients and vitamins can work in optimum conditions under the skin. It also stimulates human tissue growth.
The coenzymes catalyse bio-chemical reactions in your client’s skin cells while nucleic acid bases improve cellular communication and vitamins stimulate vital cell functions, all helping to repair and promote the growth of healthy skin cells. Collagen and elastin are vital for restoring structure to slack skin, and the amino acids encourage their production along with other important proteins. Minerals to prevent and repair skin deficiencies and anti-oxidants to protect the skin from free radicals. Provides the essential nutrients to restore and maintain healthy skin.
23 amino acids: Alanine, Arginine, Asparagine, Aspartic Acid, Cystine, Glutamine, Glutamic Acid, Glycine, Histidine, Hydroxyproline, Isoleucine,
Leucine, Lysine, Methionine, Ornithine, Phenylamine, Proline, Serine, Taurine, Threonine, Tryptophan, Tyrosine, and Valine.
18 vitamins: Ascorbic Acid, Biotin, Choline, Panthenol, Folic Acid, Inositol, Niacinamide, Nicotinic acid (Niacin), Para-Aminobenzoic Acid,
Pyridoxal hydrochloride, Pyridoxine, Riboflavin, Thiamine, Tocopherol, Vitamin A (acetate), Vitamin B12, Menadione (Vitamin K3), Vitamin D2
(Calciferol).
4 minerals: Calcium, Potassium, Magnesium, Sodium.
6 coenzymes: Cocarboxylase (TPP), Coenzyme A (CoA), Flavin Adenine Dinucleotide (FAD), Nicotinamide Adenine Dinucleotide (NAD),
Nicotinamide Adenine Dinucleotide Phosphate (NADP), and Uridine Triphosphate (UTP);
5 nucleic acids: Deoxyadenosine, Deoxycytidine, Deoxyguanosine, Deoxythymidine, and Methylcytosin.
2 reducing agents: Ascorbic Acid and Glutathione.

Where you can find it: F-XFC, F-XFC+, F-SLIM LIFT

Caffeine

Source: natural

Caffeine is a strong antioxidant known for its anti-ageing benefits. Caffeine constricts the blood vessels and helps reduce inflammation and puffiness. It also tightens and brightens the skin, reducing wrinkles and visibly smoothing away cellulite on the body. Caffeine is able to stimulate cell metabolism and specifically promotes the hydrolysis of triglycerides into free fatty acids and glycerol, thus reducing adipose storages. It has also a diuretic effect, which helps to control the liquid retention associated to cellulitis.

Where you can find it: F-EYE CONTOUR, F-XBC, F-SLIM LIFT, PPC+ CREAM

Cross-linked hyaluronic acid

Source: bio-fermentation (produced from bacteria)

Cross-linked polymer derived from naturally sourced Hyaluronic Acid. This active ingredient is commonly used in dermal fillers injections. It appears like an elastic gel with high viscosity able to form invisible biological film on the skin surface with various effects, such as moisturising, protection and wrinkles filling.

The cross-linked hyaluronic acid micro structure was studied by using scanning electron microscopy to demonstrate that it forms a 3D “breathable” layer on the surface of the skin that improves the skin barrier function, reduces the water evaporation and prevents the skin damage caused by external aggressions like UV ray, pollution, etc.

The viscosity of a crosslinked hyaluronic acid solution is 3 times higher compare to conventional hyaluronic acid solution at the same concentration, which indicates that it can bind more water molecules because of its cross-linked structure. It behaves like a “micro reservoir” delivering continuously water to the skin.

In vivo studies demonstrated that, the skin elasticity is significantly increased. After 4 weeks of application, the relative skin elasticity increasing rate reached 21.6%. Randomized, double-blind placebo-controlled evaluation were carried out on 20 patients. The result showed a significant improvement of skin smoothness appearance on 35% of the volunteers after 30 days.

Where you can find it: MESO LIFT CREAM, HA DEEP FILLER, EYE SORBET

DMAE

Source: natural

DMAE is an abbreviated term for an antioxidant membrane stabiliser called dimethylaminoethanol. DMAE strengthens skin cells and their membranes and in doing so protects the cells structure from damaging free radicals. Also it helps to defy the effects of muscular sagging. DMAE helps to tighten skin and reduce sagging, improve firmness and elasticity, smooth lines and wrinkles, and brighten the skin.

Where you can find it: F-DMAE, F-XFC+ FACE, F-LIFT+ BODY, F-GLOW LIFT

Gluconolactone

Source: natural

Gluconolactone is a lactone compound formed by removing one molecule of water from gluconic acid, soluble in water and ethanol, mild without irritation. It penetrates cells slowly because of its large molecular weight, so it has better hydrating properties compared with hydroxyl acid (AHA) and is suitable for sensitive skin. In addition, it also has the effect of anti- oxidation, anti-inflammatory, improving skin radiance and making the skin tone even. Gluconolactone is an efficient treatment for oily skin, acne and rosacea.

Where you can find it: HYALURONIC PEEL

Hyaluronic acid

Source: bio-fermentation (produced from bacteria)

Hyaluronic Acid is the most hydrated biopolymer known. In living tissues it serves as a connective tissue organizer and water holding substance. The sodium hyaluronate comes from a biotechnical safe process; it is free of contaminants and GMO. A certain level of stratum corneum hydration is essential for skin smoothness and elasticity, as well as for enzyme reactions important for skin renewal and desquamation.
Hyaluronic Acid forms a film on the skin and so hydrates the topical layers of stratum corneum. In addition this film reduces the irritating and negative influences of environment to the skin.

Where you can find it: F-HA, F-HA+, F-ACN, F-HA ULTRA, F-XFC+, F-LIFT+ FACE, F-XFC+ FACE, F-SLIM LIFT, F-GLOW LIFT, F-MESOMATRIX, F-BTX,
F-HYDRALIX, F-LIFT+ BODY, F-EYE CONTOUR, F-HAIR, F-HAIR MEN, ESSENTIAL LOTION, HYALURONIC PEEL

Lactic acid

Source: natural

Is an alpha hydroxy acid (AHA), a class of chemicals that gently exfoliate the skin. Lactic acid suitable for those who have easily irritated skin. It also helps to keep pores clear by sloughing away dead cells plus excess oil, preventing pesky pimples, blackheads or white heads from forming. Lactic acid effectively speeds up cell turnover and stimulates cell renewal, moreover, it helps improve the skin’s natural moisture factor, or the way the skin keeps itself hydrated. Basically, lactic acid helps to keep the skin moisturised and feeling less dry.

Where you can find it: F-HYDRALIX

Organic silicium

Source: synthesis

Silicium is an essential component of the skin. Indeed, by interacting with structure and elastic proteins within the dermis such as collagen fibers, elastin and proteoglycans, the silicium insures optimal skin organisation and architecture. furthermore, many studies show that silicium is capable of stimulating skin cell metabolism for enhanced cell proliferation and activity (e. g. collagen production, contraction ability…).
However, with age the amount of silicium naturally present in the skin tends to decrease. As a result, an overall collapse of the skin architecture will happen, which will in turn induce skin metabolism slow down, inevitably leading to wrinkles.
With the silanol technology, we replenish the natural pool of silicium hence allowing a complete skin restructuration for global benefits at all
levels.

• Within the epidermis, organic silicium or silica improves keratinocyte proliferation. Because of ageing, keratinocytes has a lower proliferation
rate that slowly leads to an epidermis thinning and eventually weakens skin protection and reduce skin hydration because of an increased trans-epidermis water loss. Organic silicium improves the number of proliferative keratinocytes in human reconstructed epidermis. That leads to a thickening of the epidermis for a skin that will be better protected and better hydrated.
• Within the DEJ, organic silicium improves skin cohesion. The dermal epidermal junction (DEJ) is the interface between both skin compartments. It is responsible for skin cohesion. With age, the DEJ becomes thinner and can be duplicated, hence leading to a loss of cohesion and a decreased cell communication. Organic silicium is capable of improving collagen VII expression, one of the key constituent of the DEJ in human skin explants. This leads to an improved skin cohesion and skin cell communication.
• Within the dermis, organic silicium improves collagen production. With age, all metabolisms tend to slow down. In the dermis this results in a lower proliferation rate and a lower activity of fibroblasts. There are too few collagen fibers and the skin is flaccid and wrinkled. Organic silicium stimulates fibroblast number and activity. In the dermis, there will be more fibroblasts and each one of them will produce more collagen. This strong collagen booster effect leads to a firmer and more elastic skin. Wrinkles are filled and erased.
• Within the hypodermis, organic silicium improves lipolysis. With age, there are more and more adipocytes (fat storing cells). This causes a fat accumulation leading for example to cellulite on the body and eye bags on the face. Organic silicium stimulates adipocyte ability to get rid of the fat by improving lipolysis. A treatment with organic silicium improves three folds the amount of fat released by adipocytes. cellulite is strongly reduced, skin is firmer and eye bags are reduced.

Recognised as a separate entity within the skin, the hair follicle’s formation and maintenance is linked to the interaction between its dermal and epidermal components. It is in the hair follicles that are located the actively proliferating cells that generate hair. Both the hair quality and quantity depend on the significant presence of silicium in the dermis, epidermis and the hair shaft. Organic silicium demonstrated a significant improvement on hair growth and vitality in combination with Carcinine.

Where you can find it: F-SILORG, F-XFC+ FACE, F-EYE CONTOUR, F-GLOW LIFT, F-COUPERIX, F-LIFT+ BODY,  F-MAGISTRAL, F-XBC, F-HAIR, F-HAIR MEN

Phytic acid

Source: natural

It’s a plant extract with some antioxidant and anti-inflammatory effects. Like other antioxidants, phytic acid can help to neutralise free radical damage in the skin. Moreover, it holds the ability to absorb certain minerals – specific ones that can have detrimental effects on the skin when they become too abundant. It appears to work mechanically to absorb up iron molecules in the skin, which are responsible for causing damage to DNA. Phytic acid is a gentle AHA and is great for those with sensitive skin or those with rosacea.

Where you can find it: F-COUPERIX

Probiotic complex

Source: natural

A pre/probiotic complex, spray dried on maltodextrin, made of :

• α-glucooligosaccharides (GOS), obtained by enzymatic synthesis, from vegetal substrates (corn maltose, beetroot saccharose),
• 100% pure plant juice, rich in β-fructooligosaccharides (FOS), obtained by cold pressing, of jicama or yacon tubers (Polymnia sonchifolia),
• Lactobacillus probiotic bacteria (L. casei, L. acidophilus), inactivated by tyndallization and freeze-dried. This product is used for the optimisation of the cutaneous ecoflora, the strengthening of biological defences, and the improvement of the skin radiance by a restructuring and smoothing effect.

Where you can find it: PROBIOTIX CREAM

Pyruvic acid

Source: natural

Pyruvic acid, a product of pyruvate, is a natural compound produced by the body that helps make and use energy. Because it is instrumental in the metabolism of fat, people sometimes take pyruvate supplements to lose weight. Although studies have indicated that it may be an effective weight-control supplement.

Scientists believe pyruvate exerts a fat-loss effect in several possible ways: may increase the breakdown of fat in the body; may increase muscle mass. This has been observed in some research and could also account for pyruvate’s metabolic-stimulating effect, because muscle increases metabolism; prevents fat regain and helps you keep weight off; works as an antioxidant to fight free radicals and heal the tissue damage they cause; reverses the order in which body uses energy. Normally, the body draws on carbs first for energy, then protein, and finally
fat. Remarkably, pyruvate appears to reverse that order to burn fat first for its energy needs. But why the reversal? Pyruvate may reduce insulin levels in the body. Insulin is a busy hormone. Among its duties is to promote fat storage. But if insulin levels are low, less fat is stored in fat cells – which could partially explain pyruvate’s effect on fat-burning.

 

Where you can find it: F-HAIR, F-ANTI-OX

Resorcinol & hexyl-resorcinol

Source: synthesis

Hexylresorcinol was proven to be four times more effective compare to hydroquinone, it works by modulating multiple sites in the melanogenesis pathway. It shows also other surprising functions as it increases levels of glutathione and stimulates the antioxidant defense enzymes – glutathione peroxidase and glutathione reductase. Glutathione is well known to protect the cells from oxidative injury and DNA damage. More over it has antibacterial properties which makes it an ingredient of choice for oily skin types.

Where you can find it: RADIANCE CREAM, F-MELACLEAR

Superoxide dismutase (SOD)

Source: synthesis

Superoxide dismutase is the most powerful antioxidant enzyme in the body. By protecting the skin from free radical damage, superoxide dismutase prevents visible signs of agEing. Even better, it helps repair signs of aging. It does this by promoting a youthful complexion, encouraging resilient skin. It also fights hyperpigmentation from UV damage, age spots.

Where you can find it: F-ANTI-OX

Tranexamic acid

Source: natural

Traditionally, tranexamic acid is actually a drug which has been used in surgery to stem bleeding, also studies show that it has a positive impact on melasma and hyperpigmentation. It is safe to use for all skin types and skin colours. Tranexamic acid provides a powerful and specific anti-inflammatory action, inhibiting tyrosinase synthesis in melanocytes to keratinocytes in the epidermis. Also it calms the skin and helps to restore the skin barrier. In fact, tranexamic acid decreases the skin’s sensitivity to UV.

Where you can find it: F-MELACLEAR, F-GLOW LIFT

Transdermal PPC

Source: natural & synthesis

Cellulite involves changes in the dermis and subcutaneous tissue caused by the irregular proliferation of fat cells, the so-called adipocytes. Contrary to widespread opinion, this cosmetic and medical defect affects both women and men from various age groups. Cellulite, classified as a civilisation-related disease, is associated with lifestyle, diet and the use of different types of pharmaceutics. Nowadays, there are many formulations, therapies and treatments on the market which promise instant results and the removal of the unwanted lesions. Low prices, inviting and easily available formulations, are often hardly effective, and act only superficially.

Transdermal PPC is a perfect alternative for the above-mentioned solutions. Inside the lipid bilayer vesicles of approx. 100 nm in diameter, three synergistically acting active ingredients are contained – L-carnitine, caffeine and sodium deoxycholate – which up to now have been used mainly in invasive aesthetic medicine treatments. These substances were selected in such a way as to most effectively reduce fat tissue, at the same time improving skin elasticity and firmness at the site of application, which have been proved in many studies.

•L-carnitine speeds up the energetic metabolism of fatty acids and acts as a detoxificant for skin cells.
•Sodium deoxycholate effectively liquefies the cell membranes of fat cells, the so-called adipocytes, allowing the release of the unnecessary products of metabolism (lipolysis).
•Caffeine stimulates microcirculation, thus strengthening the action of the other active ingredients. Additionally, it speeds up lipolysis, leading to an increase in the blood level of glycerol and free fatty acids.

 

Where you can find it: PPC+ CREAM

Unirepair T43

Source: natural

Repairing complex rich in amino acid: Acetyl tyrosine, proline both known for their redox properties; hydrolysed vegetable proteins (rich in energy boosters like glutamine and glutamic acid) and ATP as an energy booster. Unirepair T43 accelerates the repair process in pre and post treatments, it reduces the inflammation and the skin redness by providing amino acids that are precursors of DNA repairing enzymes but also that have direct DNA redox activity.

The DNA damage after UVB irradiations are reduced up to 50% after 5 hours.
The erythema is reduced up to 37% after 24 hours and up to 52% after 48 hours.
Unirepait T 43 is also an effective treatment to prevent UV induced cellular DNA damages. Consequences of DNA Damage: Reduction in protein synthesis, senescence (cell dormancy) and apoptosis (cell death), ageing (primary cause), skin cancer.

Where you can find it: MESO REPAIR CREAM

XS hyaluronic acid

Source: bio-fermentation (produced from bacteria)

Hyaluronic Acid is the most hydrated biopolymer known. In living tissues it serves as a connective tissue organizer and water holding substance. The sodium hyaluronate is coming from a biotechnical safe process; it is free of contaminants and GMO. XS Hyaluronic Acid which is a very low molecular weight hyaluronic acid. It is a breakthrough in anti-aging properties with increased permeation through the skin compared to high molecular weight hyaluronic acid. It rejuvenates the skin by improving its viscoelastic properties and significantly decreases deep wrinkles.

 

Where you can find it: PROBIOTIX CREAM, HYALURONIC DROPS, DEEP CLEANSER, HYALURONIC CRYO MASK, LIFT SLEEPING MASK,
HYALURONIC MOISTURIZER